Tell your doctor if you smoke or if you have recently stopped smoking. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Our Uniphyl theophylline, anhydrous Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. If the patient is vomiting, the charcoal should be administered through a nasogastric tube or after administration of an antiemetic. Phenothiazine antiemetics such as prochlorperazine or perphenazine should be avoided since they can lower the seizure threshold and frequently cause dystonic reactions. A single dose of sorbitol may be used to promote stooling to facilitate removal of theophylline bound to charcoal from the gastrointestinal tract. Sorbitol, however, should be dosed with caution since it is a potent purgative which can cause profound fluid and electrolyte abnormalities, particularly after multiple doses. Commercially available fixed combinations of liquid charcoal and sorbitol should be avoided in young children and after the first dose in adolescents and adults since they do not allow for individualization of charcoal and sorbitol dosing. Ipecac syrup should be avoided in theophylline overdoses. Although ipecac induces emesis, it does not reduce the absorption of theophylline unless administered within 5 minutes of ingestion and even then is less effective than oral activated charcoal. Moreover, ipecac induced emesis may persist for several hours after a single dose and significantly decrease the retention and the effectiveness of oral activated charcoal.
Higher doses of adenosine may be required to achieve desired effect. Increases in the dose of theophylline should not be made in response to an acute exacerbation of symptoms of chronic lung disease since theophylline provides little added benefit to inhaled beta2-selective agonists and systemically administered corticosteroids in this circumstance and increases the risk of adverse effects. A peak steady-state serum theophylline concentration should be measured before increasing the dose in response to persistent chronic symptoms to ascertain whether an increase in dose is safe. The presence of other medical problems may affect the use of this medicine.
Shomon M. Synthroid pour approbation de la FDA, restera sur le marché, mais avec la phase de production - en dehors. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. order now doxycycline mastercard otc
Tell your doctor if another doctor prescribes a new medicine or tells you to stop using a medicine that you have already been taking. Tell your doctor if you start or stop any medicine, either prescription or over the counter. Many drugs can interact with guaifenesin and theophylline. Below is just a partial list. Infasurf therapy is indicated for infants less than or equal to 72 hours of age with RDS confirmed by clinical and radiologic findings and requiring endotracheal intubation.
At first, 300 to 400 milligrams mg as a single dose, usually in the morning, or divided and given two times per day. Your doctor may adjust your dose as needed. However, the total dose is usually not more than 600 mg per day. Table V. Dosing initiation and titration as anhydrous theophylline. Increases theophylline clearance by induction of microsomal enzyme activity. Race Pharmacokinetic differences in theophylline clearance due to race have not been studied. Increased risk of ventricular arrhythmias. Severe cases, sometimes without previous warning, have led to cardiac arrhythmias, intractable seizures, and death. One study has shown an increase in fetal breathing movements when theophylline was ingested by pregnant women at 33 to 38 weeks gestation. Since fetal breathing movements are routinely used to assess fetal status in late gestation, maternal theophylline intake should be taken into account. Older adults may be more likely to have side effects from this medication. Intratracheal Suspension is a sterile, non-pyrogenic lung surfactant intended for intratracheal instillation only. It is an extract of natural surfactant from calf lungs which includes phospholipids, neutral lipids, and hydrophobic surfactant-associated proteins B and C SP-B and SP-C. It contains no preservatives. For various North American patient populations from literature reports. Different rates of elimination and consequent dosage requirements have been observed among other peoples. Metabolism Following oral dosing, theophylline does not undergo any measurable first-pass elimination. In adults and children beyond one year of age, approximately 90% of the dose is metabolized in the liver. Quibron-T will not stop an asthma attack once one has started. Be sure to always carry appropriate rescue medicine eg, bronchodilator inhaler with you in case of an asthma attack. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. During the initiation of theophylline therapy, caffeine-like adverse effects may transiently alter patient behavior, especially in school age children, but this response rarely persists.
Have started or stopped taking another medicine in the last few weeks. Safety and efficacy of caffeine citrate for treatment of apnea of prematurity have only been established in pediatric patients 28 weeks to less than 33 weeks gestational age. Patients should be instructed to inform all clinicians involved in their care that they are taking theophylline, especially when a medication is being added or deleted from their treatment. Patients should be instructed to not alter the dose, timing of the dose, or frequency of administration without first consulting their clinician. If a dose is missed, the patient should be instructed to take the next dose at the usually scheduled time and to not attempt to make up for the missed dose. This medication must be used regularly to be effective. It does not work right away and should not be used to relieve sudden breathing problems. If sudden shortness of breath occurs, use your quick-relief inhaler as prescribed. FDA pregnancy category C. It is not known whether theophylline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Theophylline is excreted into human milk and may cause irritability or other signs of mild toxicity. The concentration of theophylline in breast milk is approximately equivalent to the maternal serum concentration. The manufacturer states that serious adverse effects in the infant are unlikely unless the mother has toxic serum theophylline concentrations. The American Academy of Pediatrics considers theophylline to be compatible with breast-feeding. IV over 30 minutes one time. Horowitz DA, Jablonski W, Mehta KA "Apnea associated with theophylline withdrawal in a term neonate. precose
Pediatrics The clearance of theophylline is very low in neonates see . Theophylline clearance reaches maximal values by one year of age, remains relatively constant until about 9 years of age and then slowly decreases by approximately 50% to adult values at about age 16. Renal excretion of unchanged theophylline in neonates amounts to about 50% of the dose, compared to about 10% in children older than three months and in adults. Get medical help right away if you have any very serious side effects, including: seizures. Other medications can affect the removal of theophylline from your body, which may affect how theophylline works. Examples include cimetidine, disulfiram, fluvoxamine, interferon, mexiletine, propranolol, rifampin, drugs used to treat seizures such as carbamazepine, phenytoin St. John's wort, ticlopidine, among others. Drinking alcohol may increase the risk of side effects of Quibron-T. Talk to your doctor before drinking alcohol while you are taking Quibron-T. Prophylaxis therapy at birth with Infasurf is indicated for premature infants less than 29 weeks of gestational age at significant risk for RDS. Infasurf prophylaxis should be administered as soon as possible, preferably within 30 minutes after birth. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. The initial dose was administered within 30 minutes of birth. Repeat doses were administered at 12 and 24 hours if the patient remained intubated. Each dose was administered divided in 2 equal aliquots, and given through a side port adapter into the proximal end of the endotra cheal tube. Each aliquot was given in small bursts over 20-30 inspiratory cycles. After each aliquot was instilled, the infant was positioned with either the right or the left side dependent. Tell your doctor all medications and supplements you use. During pregnancy, Theo-24 should be taken only if prescribed. It may be harmful to a fetus. This medication can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding. Take this medication by mouth as directed by your doctor, usually once or twice daily. Since different manufacturers have different ways to take this medication, ask your doctor or pharmacist about the best times to take your brand of theophylline and if you should take the drug with or without food. Schatz M, Zeiger RS, Harden K, Hoffman CC, Chilingar L, Petitti D "The safety of asthma and allergy medications during pregnancy. Do not take other medicines unless they have been discussed with your doctor. Patients were given an initial dose and one repeat dose 12 hours later if intubation was still required. The dose was instilled in two aliquots through a side port adapter into the proximal end of the endotracheal tube. Each aliquot was given in small bursts over 20-30 inspiratory cycles. After each aliquot was instilled, the infant was positioned with either the right or the left side dependent. This medicine may add to the central nervous system CNS stimulant effects of caffeine-containing foods or beverages such as chocolate, cocoa, tea, coffee, and cola drinks. Avoid eating or drinking large amounts of these foods or beverages while using this medicine. If you have questions about this, check with your doctor. Some medical conditions may interact with Quibron. price for quinine 750 mg quinine
Caution is advised when using Quibron in CHILDREN, especially newborns with kidney problems; they may be more sensitive to its effects. Patients should be instructed to take this medication each morning at approximately the same time and not to exceed the prescribed dose. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Do not use this medication if you are allergic to theophylline. Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding. Refer to for further information regarding table. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. In patients with end-stage renal disease, 3-methylxanthine may accumulate to concentrations that approximate the unmetabolized theophylline concentration. Caffeine concentrations are usually undetectable in adults regardless of renal function. In neonates, caffeine may accumulate to concentrations that approximate the unmetabolized theophylline concentration and thus, exert a pharmacologic effect. What other drugs will affect Quibron guaifenesin and theophylline? Increasing the rate of theophylline clearance by extracorporeal methods may rapidly decrease serum concentrations, but the risks of the procedure must be weighed against the potential benefit. Charcoal hemoperfusion is the most effective method of extracorporeal removal, increasing theophylline clearance up to six fold, but serious complications, including hypotension, hypocalcemia, platelet consumption and bleeding diatheses may occur. Hemodialysis is about as efficient as multiple-dose oral activated charcoal and has a lower risk of serious complications than charcoal hemoperfusion. Hemodialysis should be considered as an alternative when charcoal hemoperfusion is not feasible and multiple-dose oral charcoal is ineffective because of intractable emesis. Stenius-Aarniala B, Riikonen S, Teramo K "Slow-release theophylline in pregnant asthmatics. Caffeine may increase some of the side effects of theophylline.
In patients with chronic obstructive pulmonary disease COPD clinical studies have shown that theophylline decreases dyspnea, air trapping, the work of breathing, and improves contractility of diaphragmatic muscles with little or no improvement in pulmonary function measurements. Do not take medications containing aminophylline or oxtriphylline while using theophylline. What happens if I overdose Theo-24? Notify your doctor if you develop a new illness, especially if it is accompanied by fever; if a chronic illness becomes worse; if you start or stop smoking cigarettes or marijuana; or if another doctor prescribes a new medication or tells you to stop using a medication that you have already been taking. After multiple doses of theophylline, steady state is reached in 30-65 hours average 40 hours in adults. At steady state, on a dosage regimen with 6-hour intervals, the expected mean trough concentration is approximately 60% of the mean peak concentration, assuming a mean theophylline half-life of 8 hours. The difference between peak and trough concentrations is larger in patients with more rapid theophylline clearance. In patients with high theophylline clearance and half-lives of about 4-5 hours, such as children age 1 to 9 years, the trough serum theophylline concentration may be only 30% of peak with a 6-hour dosing interval. Tell your doctor all medications and supplements you use. During pregnancy, Uniphyl should be used only when prescribed. Changes in your body during the last 3 months of pregnancy may affect the amount of this drug in your blood. Your doctor should monitor the amount of drug in your blood, as well as any side effects, so your dose may be changed if needed. Some MEDICINES MAY INTERACT with Quibron-T. Theophylline is very similar to aminophylline and oxtriphylline. Do not take medications containing aminophylline or oxtriphylline while using theophylline. Use: Short-term treatment of apnea of prematurity in infants. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. Pharmacokinetic differences in theophylline clearance due to race have not been studied. elov.info lamotrigine
Before you have any medical tests, tell the medical doctor in charge that you or your child are using this medicine. The results of some tests may be affected by this medicine. Some foods may change the effectiveness or increase the side effects of Quibron. Talk to your doctor about how you should take Quibron with regard to food. Do not suddenly change your diet or eating habits without first checking with your doctor. Available data suggests that drug administration at the time of food ingestion may influence the absorption characteristics if some or all theophylline controlled-release products, resulting in serum values different from those found after administration in the fasting state. Caffeine and alcohol can increase the side effects of this medication. Avoid drinking large amounts of beverages containing alcohol or caffeine such as coffee, tea, colas eating large amounts of chocolate, or taking nonprescription products that contain caffeine. If you get sick or have a fever while taking this medication, tell your doctor right away. The dose of your medicine may need to be adjusted. This drug may cause nervousness, tremor, insomnia, nausea, and loss of appetite; consult your physician if symptoms persist or worsen. Rx only Manufactured by: ONY, Inc. Amherst, NY 14228 Rev. Steniusaarniala B, Riikonen S, Teramo K "Slow-release theophylline in pregnant asthmatics. Dosing Guidelines, Table VI. Do not start or stop smoking without first talking to your doctor. Smoking changes the way your body uses theophylline, and you may need to use a different dose. cheap lotrisone comp
While the mechanisms of action of theophylline are not known with certainty, studies in animals suggest that bronchodilatation is mediated by the inhibition of two isozymes of phosphodiesterase PDE III and, to a lesser extent, PDE IV while non-bronchodilator prophylactic actions are probably mediated through one or more different molecular mechanisms, that do not involve inhibition of PDE III or antagonism of adenosine receptors. Take this medication exactly as it was prescribed for you. Treatment of seizures Because of the high morbidity and mortality associated with theophylline-induced seizures, treatment should be rapid and aggressive. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. While the mechanisms of action of theophylline are not known with certainty, studies in animals suggest that bronchodilation is mediated by the inhibition of two isozymes of phosphodiesterase PDE III and, to a lesser extent, PDE IV while non-bronchodilator prophylactic actions are probably mediated through one or more different molecular mechanisms that do not involve inhibition of PDE III or antagonism of receptors. Begin the maintenance dose 24 hours after the loading dose. The dosage is based on your medical condition, response to treatment, age, weight, lab tests theophylline blood levels and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Theophylline decreases phenytoin absorption. To guide a dose increase, the blood sample should be obtained at the time of the expected peak serum theophylline concentration; 5-6 hours after a dose at steady-state, drawn more than 6 hours after the dose. For most patients, steady-state will be reached after 3 days of dosing when no doses have been missed, no extra doses have been added, and none of the doses have been taken at unequal intervals.
Table IV. Manifestations of theophylline toxicity. This information is a summary only. It does not contain all information about Quibron-T. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider. Where can I get more information? The listing of drugs in Tables II and III are current as of October 8, 1996. New interactions are continuously being reported for theophylline, especially with new chemical entities. The listing of drugs in Table II is current as of June 2004. The listing of drugs in Table III is current as of January 2, 1996. New interactions are continuously being reported for theophylline, especially with new chemical entities. Refer to for information regarding table. Discard any unused portion of the medication, and oral solution vials containing discolored solution or visible particulate matter. Theophylline has been studied in Ames salmonella, in vivo and in vitro cytogenetics, micronucleus and Chinese hamster ovary test systems and has not been shown to be genotoxic. Your dosage needs may change if you are ill, or if your doctor changes your brand, strength, or type of theophylline. You will need regular medical tests to be sure you are using the right dose. Do not change your medication dose or schedule without your doctor's advice. Lithium dose required to achieve a therapeutic serum concentration increased an average of 60%. Lab tests, including blood theophylline levels, may be performed while you use Quibron. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Quibron-T is to be used only by the patient for whom it is prescribed. Do not share it with other people. Do not stop taking any medications without consulting your healthcare provider. THE ADMINISTRATION OF EXOGENOUS SURFACTANTS, INCLUDING Infasurf, OFTEN RAPIDLY IMPROVES OXY GENATION AND LUNG COMPLIANCE. Following administration of Infasurf, patients should be carefully monitored so that oxygen therapy and ventilatory support can be modified in response to changes in respiratory status. Infasurf therapy is not a substitute for neonatal intensive care. Optimal care of premature infants at risk for RDS and new born infants with RDS who need endotracheal intubation requires an acute care unit organized, staffed, equipped, and experienced with intubation, ventilator management, and general care of these patients. flonase in canada online
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Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; confusion; diarrhea; dizziness; fast breathing; heart rhythm problems or irregular heartbeats; nausea; persistent headache; seizures; sleeplessness; tremors; vomiting. The drugs listed in Table II have the potential to produce clinically significant pharmacodynamic or pharmacokinetic interactions with theophylline. The information in the “Effect” column of Table II assumes that the interacting drug is being added to a steady-state theophylline regimen. Decreases theophylline clearance by inhibiting cytochrome P450 1A2. antabuse
Avoid eating foods that are high in fat within 1 hour before or after taking theophylline. Larger diazepam doses may be required to produce desired level of sedation. Discontinuation of theophylline without reduction of diazepam dose may result in respiratory depression. Serum theophylline concentration measurements are readily available and should be used to determine whether the dosage is appropriate. HPLC techniques. Caffeine and xanthine metabolites in neonates or patients with renal dysfunction may cause the reading from some dry reagent office methods to be higher than the actual serum theophylline concentration.
Avoid drinks or foods that contain caffeine, such as coffee, tea, cola, and chocolate. Take Quibron-T at evenly spaced times throughout the day. Taking Quibron-T at the same time each day will help you remember to take it. Contact your doctor with any questions or concerns about the best way to take Quibron-T. Prior to treatment initiation of caffeine citrate, measure baseline serum levels of caffeine in infants previously treated with theophylline and those born to mothers who consumed caffeine prior to delivery. Use Quibron with caution in the ELDERLY; they may be more sensitive to its effects. purchase cheapest prometrium mastercard australia
Do not share this medication with others. Clearance represents the volume of blood completely cleared of theophylline by the liver in one minute. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Many drugs can interact with theophylline and not all possible interactions are listed in this medication guide. actos